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6778942 
Journal Article 
Review 
Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanisms 
Larson, AJ; Symons, JD; Jalili, T 
2012 
0 
Advances in Nutrition
ISSN: 2161-8313
EISSN: 2156-5376 
3 
1 
39-46 
English 
22332099 
WOS:000313219800004 
Epidemiological studies beginning in the 1990s have reported that intake of quercetin, a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is inversely related to cardiovascular disease. More recent work using hypertensive animals and humans (>140 mm Hg systolic and >90 mm Hg diastolic) indicates a decrease in blood pressure after quercetin supplementation. A number of proposed mechanisms may be responsible for the observed blood pressure decrease such as antioxidant effects, inhibition of angiotensin-converting enzyme activity, and improved endothelium-dependent and -independent function. The majority of these mechanisms have been identified using animal models treated with quercetin, and relatively few have been corroborated in human studies. The purpose of this review is to examine the evidence supporting the role of quercetin as a potential therapeutic agent and the mechanisms by which quercetin might exert its blood pressure-lowering effect.