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HERO ID
6780516
Reference Type
Journal Article
Subtype
Review
Title
DNA methylation, a hand behind neurodegenerative diseases
Author(s)
Lu, H; Liu, X; Deng, Y; Qing, H
Year
2013
Is Peer Reviewed?
Yes
Journal
Frontiers in Aging Neuroscience
ISSN:
1663-4365
Volume
5
Page Numbers
85
Language
English
PMID
24367332
DOI
10.3389/fnagi.2013.00085
Web of Science Id
WOS:000328263500002
Abstract
Epigenetic alterations represent a sort of functional modifications related to the genome that are not responsible for changes in the nucleotide sequence. DNA methylation is one of such epigenetic modifications that have been studied intensively for the past several decades. The transfer of a methyl group to the 5 position of a cytosine is the key feature of DNA methylation. A simple change as such can be caused by a variety of factors, which can be the cause of many serious diseases including several neurodegenerative diseases. In this review, we have reviewed and summarized recent progress regarding DNA methylation in four major neurodegenerative diseases: Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS). The studies of these four major neurodegenerative diseases conclude the strong suggestion of the important role DNA methylation plays in these diseases. However, each of these diseases has not yet been understood completely as details in some areas remain unclear, and will be investigated in future studies. We hope this review can provide new insights into the understanding of neurodegenerative diseases from the epigenetic perspective.
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