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6782620 
Journal Article 
Protective effects of calcium on copper toxicity in Pelteobagrus fulvidraco: Copper accumulation, enzymatic activities, histology 
Chen, QL; Luo, Z; Zheng, JL; Li, XD; Liu, CX; Zhao, YH; Gong, Y; , 
2012 
Yes 
Ecotoxicology and Environmental Safety
ISSN: 0147-6513
EISSN: 1090-2414 
ACADEMIC PRESS INC ELSEVIER SCIENCE 
SAN DIEGO 
126-134 
22019308 
WOS:000297663100015 
The present study was conducted to determine interactive effects of waterborne co-exposure of copper (Cu) and calcium (Ca) on Cu accumulation, enzymatic activities and histology in yellow catfish Pelteobagrus fulvidraco and test the prediction that Ca could protect against Cu-induced toxicity in the fish species. Yellow catfish were exposed to 0, 1.0, 2.0 mg Cu/l, in combination with 0 and 50 mg Ca/l. Waterborne Cu and Ca co-exposure influenced the majority of tested enzymatic activities (succinate dehydrogenase, malic dehydrogenase, lactate dehydrogenase, lipoprotein lipase and hepatic lipase), and changed Cu contents in several organs (gill, liver, kidney, gastrointestine and muscle). For histological observations, at the same Ca level, waterborne Cu exposure induced injuries in gills and liver. However, Ca addition seemed to mitigate the severity of Cu-induced injuries. Thus, our study demonstrated that Ca had the capacity to reduce Cu toxicity in P. fulvidraco. (C) 2011 Elsevier Inc. All rights reserved.