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678425 
Journal Article 
Studies on the effects of phthalate esters on the biological system: (Part 3). The in vitro metabolism of dibutyl phthalate in the small intestines of rats 
Kaneshima, H; Yamaguchi, T; Itoh, K 
1978 
Yes 
Bulletin of Environmental Contamination and Toxicology
ISSN: 0007-4861
EISSN: 1432-0800 
NIOSH/00168169 
20 
6 
725-728 
English 
749972 
WOS:A1978GM85800002 
The previous studies in this series (Yamaguchi et al. 1976; Kaneshima et al. 1976) indicated that orally administered di-n-butyl phthalate (DBP) to mice or rats was readily absorbed from the gastrointestinal tract and metabolized rapidly in the small intestine, liver and kidneys. Additionally, it was also found in these studies that monobutyl phthalate (MBP) and its glucuronide were excreted in rat bile as the main metabolies after the oral administration of DBP. Recently, Rowland et al. (1977) described the important role of intestinal hydrolysis in the metabolism of PAE. On the other hand, studies on the toxic effects of phthalate monoesters have recently increased (Yagi et al. 1977; Carter et al. 1977; Takahashi 1977). Therefore, it is of interest to ascertain the main metabolites and the rate of metabolism of PAE in the small intestine from the viewpoint of toxicology. The present paper describes the in vitro metabolism of DBP by the small intestine homogenates of rats. 
Animals; Chromatography, Gas; Dibutyl Phthalate/ metabolism; Intestine, Small/ metabolism; Male; Phthalic Acids/ metabolism; Rats; Time Factors