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679093 
Book/Book Chapter 
Di(2-ethylhexyl) phthalate 
American Conference of Governmental Industrial Hygienists :: ACGIH 
2001 
American Conference of Governmental Industrial Hygienists 
Cincinnati, OH 
Documentation of threshold limit values for chemical substances and physical agents and biological exposure indices for 2001 
English 
is a chapter of 594530 Documentation of the threshold limit values and biological exposure indices
A TLV TWA of 5 mg/m3 is recommended for occupational exposure to di(2-ethylhexyl) phthalate (DEHP). This value is intended to minimize the potential for irritation and possible neurotoxicity. DEHP is considered a substance of low toxicity by all routes of exposure. An A3, Confirmed Animal Carcinogen with Unknown Relevance to Humans, notation is assigned based on the liver tumors reported in rats and mice fed DEHP in their diets. Differences in the metabolic pathways of rodents and primates for DEHP and its metabolites may account for the liver cancer observed in rats and mice. Sufficient data were not available to recommend Skin or SEN notations or a TLV-STEL. 
human; acute toxicity; animal; carcinogenicity; carcinogens; case report; chronic effect; chronic toxicity; diet; genetic toxicity; human exposure; humans; hypersensitivity; irritancy; leather industry; liver; metabolites; mice; mutagens; nervous system; neurotoxicity; occupational exposure; phthalate; plastic industry; primates; rats; reproductive and developmental tests; reproductive effect; respiratory system; skin; subacute toxicity; subchronic toxicity; teratogens; toxicity; toxicokinetics 
7th ed. 
9781882417438