Health & Environmental Research Online (HERO)


Print Feedback Export to File
6792288 
Journal Article 
A Systematic Review and Meta-Analysis of Telmisartan vs Valsartan in the Management of Essential Hypertension 
Zheng, Z; Lin, S; Shi, H; , 
2010 
Yes 
Journal of Clinical Hypertension
ISSN: 1524-6175
EISSN: 1751-7176 
WILEY-BLACKWELL PUBLISHING, INC 
MALDEN 
414-421 
20591086 
WOS:000279458900004 
This was a systematic assessment of the efficacy and safety of telmisartan and valsartan for the management of blood pressure (BP) in patients with essential hypertension. The authors reviewed randomized controlled trials (RCTs) and quasi-RCTs comparing telmisartan and valsartan for the management of essential hypertension in which the participants were followed for at least 6 weeks. When a meta-analysis was possible, included studies were analyzed by Review Manager 5.0 provided by Cochrane Collaboration Group. Statistics were calculated as weight mean differences (WMDs) and relative risk with a random-effect model. A total of 6 RCTs with 3762 patients were included in this meta-analysis. When the authors combined data from all treatment categories as a group, no difference was found between telmisartan and valsartan in reduction of systolic BP and diastolic BP. In subgroup analysis, telmisartan showed a significant benefit on lowering systolic BP and diastolic BP (WMD, -2.88; 95% confidence interval [CI], -5.03 to -0.73; P<.01; and WMD,-1.73; 95% CI, -2.47 to -0.98; P<.01; respectively). It was found that telmisartan had a higher rate of management of clinical BP compared with valsartan (relative risk, 1.09; 95% CI, 1.00-1.19; P=.05). No difference was found in the incidence of adverse events. Telmisartan's BP-lowering capabilities were comparable to those of valsartan in monotherapy. When combined with hydrochlorothiazide, telmisartan was more effective than valsartan. Telmisartan had the same safety in the treatment of essential hypertensive patients in comparison with valsartan. J Clin Hypertens (Greenwich). 2010;12:414-421. (C) 2010 Wiley Periodicals, Inc.