Effect of di-2-ethylhexyl phthalate in the female rat: Inhibition of hepatic and adrenal sterologenesis in vitro | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

679234

Reference Type

Journal Article

Title

Effect of di-2-ethylhexyl phthalate in the female rat: Inhibition of hepatic and adrenal sterologenesis in vitro

Author(s)

Bell, FP

Year

1980

Is Peer Reviewed?

Yes

Journal

Bulletin of Environmental Contamination and Toxicology
ISSN: 0007-4861
EISSN: 1432-0800

Publisher

Springer-Verlag

Volume

Issue

Page Numbers

54-58

Language

English

PMID

7357111

DOI

10.1007/BF01608075

Web of Science Id

WOS:A1980HY13500010

URL

http://link.springer.com/10.1007/BF01608075
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Abstract

In previous reports from this laboratory, we have shown that feeding the plasticizer di-2-ethylhexyl phthalate (DEHP) to rats results in inhibition of sterologenesis in liver and various other tissues (BELL 1976, BELL et al. 1978a, BELL et al. 1979). Most of these studies, however, have been conducted in male animals. The present report describes the additional observations that DEHP feeding inhibits hepatic sterologenesis in normal female rats and that the pregnant rat may be less sensitive to the effects of DEHP because of DEHP distribution to the developing fetal tissue. In addition, this report gives evidence that DEHP feeding inhibits sterologenesis in adrenal glands from female, as well as male, rats.

Keywords

Adrenal Glands; Animals; biosynthesis; Diethylhexyl Phthalate; drug effects; Female; Lipid Metabolism; Liver; Male; metabolism; Mevalonic Acid; Phthalic Acids; Rats; Squalene; Sterols; toxicity