The developing utility of zebrafish models of neurological and neuropsychiatric disorders: A critical review | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

6792531

Reference Type

Journal Article

Title

The developing utility of zebrafish models of neurological and neuropsychiatric disorders: A critical review

Author(s)

Fontana, BD; Mezzomo, NJ; Kalueff, AV; Rosemberg, DB; ,

Year

2018

Is Peer Reviewed?

Yes

Journal

Experimental Neurology
ISSN: 0014-4886
EISSN: 1090-2430

Publisher

ACADEMIC PRESS INC ELSEVIER SCIENCE

Location

SAN DIEGO

Page Numbers

157-171

PMID

28987462

DOI

10.1016/j.expneurol.2017.10.004

Web of Science Id

WOS:000419261500014

Abstract

Zebrafish (Danio rerio) have become a powerful tool in neuroscience research due to their genetic tractability, molecular/physiological conservation, small body size, ease of experimental manipulations in vivo, and rich behavioral repertoire. Zebrafish models and tests are particularly useful in genetics research, neurophenotyping, CNS drug screening, as well as in modeling complex neurological and psychiatric disorders. Here, we discuss selected examples of successful application of zebrafish models to mimicking various aspects of brain pathology, and emphasize their developing utility for studying the underlying molecular and genetic mechanisms. We also summarize recent advances in zebrafish-based CNS disease modeling, and outline new research strategies that may significantly improve translational neuroscience and experimental neurology research, and drug discovery.