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6797966 
Journal Article 
Review 
Inflammation, Immunity, and amyotrophic lateral sclerosis: I. Etiology and pathology 
Lyon, MS; Wosiski-Kuhn, M; Gillespie, R; Caress, J; Milligan, C 
2019 
1 
Muscle and Nerve
ISSN: 0148-639X
EISSN: 1097-4598 
59 
1 
10-22 
English 
29979464 
WOS:000454609500008 
Amyotrophic lateral sclerosis (ALS) is a severely debilitating disease characterized by progressive degeneration of motor neurons. Charcot first described ALS in 18691 ; however, its pathogenesis remains unknown, and effective treatments remain elusive. It is apparent that new paradigms must be investigated to understand the effectors of ALS, including inflammation, immune responses, and the body's response to stress and injury. Herein we discuss the potential role of the immune system in ALS pathogenesis and critically review evidence from patient and animal studies. Although immune system components may indeed play a role in ALS pathogenesis, studies implicating immune cells, antibodies, and cytokines in early disease pathology are limited. We propose more focused studies that examine the role of the immune system together with characterized pathogenesis to determine when, where, and if immune and inflammatory processes are critical to disease progression, and thus worthy targets of intervention. Muscle Nerve 59:10-22, 2019.