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6801528 
Journal Article 
Review 
The sympathetic nervous system and blood pressure in humans: implications for hypertension 
Fisher, JP; Paton, JF 
2012 
Yes 
Journal of Human Hypertension
ISSN: 0950-9240
EISSN: 1476-5527 
26 
8 
463-475 
English 
21734720 
WOS:000306360500001 
A neurogenic component to primary hypertension (hypertension) is now well established. Along with raised vasomotor tone and increased cardiac output, the chronic activation of the sympathetic nervous system in hypertension has a diverse range of pathophysiological consequences independent of any increase in blood pressure. This review provides a perspective on the actions and interactions of angiotensin II, inflammation and vascular dysfunction/brain hypoperfusion in the pathogenesis and progression of neurogenic hypertension. The optimisation of current treatment strategies and the exciting recent developments in the therapeutic targeting of the sympathetic nervous system to control hypertension (for example, catheter-based renal denervation and carotid baroreceptor stimulation) will be outlined.