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6803290 
Journal Article 
Neuroprotective effects of Lepidium meyenii (Maca) 
Pino-Figueroa, A; Nguyen, D; Maher, TJ 
2010 
Yes 
Annals of the New York Academy of Sciences
ISSN: 0077-8923
EISSN: 1749-6632 
1199 
77-85 
English 
20633111 
WOS:000282838900008 
The neuroprotective activity of the plant Lepidium meyenii (Maca) was studied in two experimental models: in vitro and in vivo. Crayfish neurons were pretreated with vehicle or the pentane extract from Maca, subjected to H(2)O(2), and their viability determined microscopically and chemically. A significant concentration-neuroprotective effect relationship was demonstrated. The pentane extract was then administered intravenously to rats prior to and following middle cerebral artery occlusion. While infarct volumes were decreased for the lower dose, higher doses increased infarct volumes compared to controls. These results suggest a potential application of Maca as a neuroprotectant.