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6811106 
Journal Article 
Review 
Dynamics of DNA methylation in aging and Alzheimer's disease 
Irier, HA; Jin, P 
2012 
Yes 
DNA and Cell Biology
ISSN: 1044-5498
EISSN: 1557-7430 
31 Suppl 1 
S42-S48 
English 
22313030 
WOS:000309979500006 
Gene expression is modulated by epigenetic factors that come in varying forms, such as DNA methylation, histone modifications, microRNAs, and long noncoding RNAs. Recent studies reveal that these epigenetic marks are important regulatory factors in brain function. In particular, DNA methylation dynamics are found to be essential components of epigenetic regulation in the mammalian central nervous system. In this review, we provide an overview of the literature on DNA methylation in neurodegenerative diseases, with a special focus on methylation of 5-position of cytosine base (5mC) and hydroxymethylation of 5-position of cytosine base (5hmC) in the context of neurodegeneration associated with aging and Alzheimer's disease.