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HERO ID
6812747
Reference Type
Journal Article
Title
The Role of Mitochondria in Reactive Oxygen Species Generation and Its Implications for Neurodegenerative Diseases
Author(s)
Kausar, S; Wang, F; Cui, H; ,
Year
2018
Volume
7
Issue
12
Page Numbers
274
Language
English
PMID
30563029
DOI
10.3390/cells7120274
Web of Science Id
WOS:000455320700052
URL
http://www.mdpi.com/2073-4409/7/12/274
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Abstract
Mitochondria are dynamic cellular organelles that consistently migrate, fuse, and divide to modulate their number, size, and shape. In addition, they produce ATP, reactive oxygen species, and also have a biological role in antioxidant activities and Ca2+ buffering. Mitochondria are thought to play a crucial biological role in most neurodegenerative disorders. Neurons, being high-energy-demanding cells, are closely related to the maintenance, dynamics, and functions of mitochondria. Thus, impairment of mitochondrial activities is associated with neurodegenerative diseases, pointing to the significance of mitochondrial functions in normal cell physiology. In recent years, considerable progress has been made in our knowledge of mitochondrial functions, which has raised interest in defining the involvement of mitochondrial dysfunction in neurodegenerative diseases. Here, we summarize the existing knowledge of the mitochondrial function in reactive oxygen species generation and its involvement in the development of neurodegenerative diseases.
Keywords
electron transport chain; mitochondria; neurodegenerative diseases; oxidative damage
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