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6812767 
Journal Article 
Review 
Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases 
Nakamura, T; Naguro, I; Ichijo, H; , 
2019 
1 
Biochimica et Biophysica Acta. General Subjects
ISSN: 0304-4165
EISSN: 1872-8006 
1863 
9 
1398-1409 
English 
31229492 
WOS:000480673100009 
Iron is essential for many types of biological processes. However, excessive iron can be cytotoxic and can lead to many diseases. Since ferroptosis, which is an iron-dependent regulated form of necrosis, was recently discovered, iron and iron-catalysed oxidative stress have attracted much interest because of their sophisticated mechanism of cellular signalling leading to cell death and associated with various diseases.