Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
6815758
Reference Type
Journal Article
Subtype
Review
Title
Apoptosis in sepsis: Mechanisms, clinical impact and potential therapeutic targets
Author(s)
Ayala, A; Perl, M; Venet, F; Lomas-Neira, J; Swan, R; Chung, CS
Year
2008
Is Peer Reviewed?
Yes
Journal
Current Pharmaceutical Design
ISSN:
1381-6128
EISSN:
1873-4286
Volume
14
Issue
19
Page Numbers
1853-1859
Language
English
PMID
18691096
DOI
10.2174/138161208784980617
Web of Science Id
WOS:000259447700004
Abstract
The inability of present therapies to mitigate the devastating effects of sepsis and multiple organ failure in the critically ill patient indicates that more knowledge of the pathophysiology of sepsis is needed if we are to develop better, more effective interventions. This review will examine the concept that a portion of the immune and organ dysfunctions encountered in the septic rodent/ patient is a reflection of not only the types of cells stimulating/ mediating the apoptotic response, but also the varying capacity of the target cell in a given tissue/ organ to perceive these death receptor stimuli as either an apoptotic, inflammatory and/or necrotic signal. We hope the discussion of such studies provides not only new insight into the pathobiology of sepsis, but also suggests possible therapeutic targets for the management of this devastating condition.
Keywords
sepsis; mice; human; death-receptor pathway; mitochondrial pathway; immune and organ dysfunction
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity