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HERO ID
68175
Reference Type
Journal Article
Title
Neurobehavioral effects of long-term exposure to xylene and mixed organic solvents in shipyard spray painters
Author(s)
Ruijten, MW; Hooisma, J; Brons, JT; Habets, CE; Emmen, HH; Muijser, H
Year
1994
Is Peer Reviewed?
1
Journal
NeuroToxicology
ISSN:
0161-813X
EISSN:
1872-9711
Volume
15
Issue
3
Page Numbers
613-620
Language
English
PMID
7854596
Web of Science Id
WOS:A1994PN14800022
Abstract
A cross-sectional study was performed in shipyard painters exposed to organic solvents and age-matched referents. The work duties of the painters mainly involved spray painting with solvent-based paints containing > 50% xylene. Testing methods consisted of a symptoms questionnaire, measurement of peripheral sensory and motor nerve parameters and computerized performance tests. Results indicate that complaints regarding mood changes, equilibrium and fatigue were more severe in painters than in referents, but were not related to the estimated life-time exposure index. Decreased nerve function was observed in the lower extremities and to some extent in the upper extremities. The refractory period appeared to be a sensitive parameter in motor nerves. Most neurophysiological parameters investigated were significantly related to the exposure index. Behavioral testing revealed impairment of simple visuo-motor performance and complex perceptual coding. A relationship between effects on perceptual coding and the exposure index was also demonstrated.
Tags
IRIS
•
Trimethylbenzenes (Interagency Science Discussion Draft)
SAB References
Cited
Cited August 2016
Cited Toxicological Review
Cited Supplemental Information
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