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HERO ID
6820439
Reference Type
Journal Article
Subtype
Review
Title
Angiotensin II type 1 receptor polymorphisms and susceptibility to hypertension: a HuGE review
Author(s)
Mottl, AK; Shoham, DA; North, KE
Year
2008
Is Peer Reviewed?
Yes
Journal
Genetics in Medicine
ISSN:
1098-3600
EISSN:
1530-0366
Volume
10
Issue
8
Page Numbers
560-574
Language
English
PMID
18641512
DOI
10.1097/GIM.0b013e3181809613
Web of Science Id
WOS:000258736200002
Abstract
The angiotensin II type 1 receptor (AGTR1) plays an integral role in blood pressure control, and is implicated in the pathogenesis of hypertension. Polymorphisms within this gene have been extensively studied in association with hypertension; however, findings are conflicting. To clarify these data, we conducted a systematic review of association studies of AGTR1 polymorphisms and hypertension, and performed a meta-analysis of the rs5186 variant. Results show that the currently available literature is too heterogeneous to draw meaningful conclusions. The definition of hypertension and gender composition of individual studies helps to explain this heterogeneity. Although the structure and splicing pattern of AGTR1 would suggest a likely effect of polymorphisms within the promoter region on gene function, few studies have been conducted thus far. In conclusion, there is insufficient evidence that polymorphisms in the AGTR1 gene are risk factors for hypertension. However, most studies are inadequately powered, and larger well-designed studies of haplotypes are warranted.
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