US EPA

6821300 

Journal Article 

The colorimetric estimation of N(2-pyridyl) substituted anti-histamine drugs††This paper is based, in part, on a thesis presented to the Graduate School of the University of Southern California in partial fulfillment of the requirements for the degree of M.S. in Pharmacy 

Jones, HMAUBES 

1949 

38 

11 

579-580 

http://www.sciencedirect.com/science/article/pii/S0095955315317248
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Tripelennamine with cyanogen bromide in a solution of potassium acid phthalate forms, upon the subsequent addition of aniline, a yellow-colored compound which obeys Beer's law. This reaction may be used to determine from one-half to ten mg./ml. of tripelennamine (Pyribenzamine) in solution. Aqueous extracts of the tablets, elixir, and cream gave results consistent with other methods of assay. Urinary excretion of tripelennamine after oral administration was also estimated by this colorimetric method. The extension of this method to the assay of other N(2-Pyridyl) substituted antihistamines in Pharmaceuticals and urine has shown promising results, and colored compounds suitable for colorimetric estimation have been obtained with thenylpyramine (Histadyl) and pyranisamine (Neo-Antergan).