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6836767 
Journal Article 
Toxicity of p-Aminobenzoic Acid 
Scott, CC; Robbins, EB 
1942 
1 
Proceedings of the Society for Experimental Biology and Medicine
ISSN: 0037-9727
EISSN: 1525-1373 
49 
2 
184-186 
Summary1. In mice, rats, and dogs, the acute toxicity of p-aminobenzoic acid by mouth has been determined. The drug is more toxic to mice and dogs than to rats. By intravenous injection the sodium salt of p-aminobenzoic acid is more toxic to rats than to mice. 2. Oral doses of p-aminobenzoic acid greater than 1.0 g per kg to dogs may cause death accompanied by acute gastro-enteritis and hemorrhages into the small intestine. Acute necrosis of the liver may result from doses of 2.0 g per kg or larger. 3. Rats tolerate daily doses of 1.4 g per kg by mouth for about a month without inhibition of growth or pathological changes.