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6837231 
Journal Article 
[The biotransformation of propiverin hydrochloride (Mictonorm)] 
Göber, B; Dressler, K; Franke, P 
1988 
Yes 
Die Pharmazie
ISSN: 0031-7144 
43 
2 
96-98 
German 
3393595 
Propiverine hydrochloride [1; hydrochloride of O-n-Propyl-(N-methylpiperidinyl-4)-benzilate; Mictonorm] is metabolized after p.o. application of 25 mg/kg on rats almost completely. Besides of small amounts of unchanged 1 in urine were detected the phase-I metabolites N-methylpiperidinyl(4)-benzilate (2), 2,2-diphenyl-5-methyl-1, 4-dioxan-3-on (3), N-oxide of 2 (4), benzilic acid (5) and O-n-propylbenzilic acid (6) using ms, dc and hplc comparison of the isolated compounds with authentic samples. The structure of further metabolites, i.e. monohydroxy-benzophenone (7), acetoxy-1-derivatives (8) and ethylbenzilate (9) were elucidated by high resolution MS. 
Benzilates; Parasympatholytics; propiverine; Animals; Benzilates/pharmacokinetics; Biotransformation; Chromatography; High Pressure Liquid; In Vitro Techniques; Mass Spectrometry; Parasympatholytics/pharmacokinetics; Inbred Strains