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Citation
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HERO ID
6840382
Reference Type
Journal Article
Title
Synthesis of glycopeptide derivatives of glycyrrhizinic acid and their immunomodulatory properties
Author(s)
Baltina, LAICBSCUBASU; Sakhautdinova, GM; Zarudii, FZ; Lazareva, DN; Tolstikov, GA; Davydova, VA
Year
1990
Volume
24
Issue
2
Page Numbers
110-113
Abstract
The anti-inflammatory activity, low toxicity and absence of serious side effects provide a rationale for examining new synthetic derivatives of glycyrrhizinic acid as medicinal compounds. The syntheses of the glycopeptides IIa-g were carried out by condensing glycoside I without prior protection with the hydrochlorides of the methyl and tert-butyl esters of optically pure aminoacids and dipeptides using the method of activated (N-hydroxysuccinimide) esters in the presence of N.N'-dicyclo hexylcarbodiimide and triethylamine in tetrahydrofuran and dioxane.
Keywords
inflammation
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OPPT REs
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OPPT_1,4-Dioxane_D. Exposure
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