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6849345 
Journal Article 
pK(a) stability constants and UV/VIS spectral behaviour of selected curcumin analogues 
Dietze, F; Dietze, F; Arrieta, AF; Arrieta, AF; Zimmer, U; Zimmer, U 
1997 
Yes 
Die Pharmazie
ISSN: 0031-7144 
52 
4 
302-306 
English 
WOS:A1997WU58800010 
The pK(a) and stability constants of selected curcumin analogues, including demethoxycurcumin, were studied in dioxane/water 75:25 (v/v), and these results were compared with our earlier studies. Compounds with beta-tricarbonyl structure show comparatively low pK(a) values. The only compound with merocyaninic character shows a moderate high pK(a) value in agreement with its particular physical properties. Repeated pK(a) determinations for curcumin under different conditions reveal that the first proton's splitting off in alkaline medium occurs at the phenolic group. PPP calculations qualitatively support the results of these potentiometric experiments.< 
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