Kinetics and mechanistic study of acid-catalysed hydrolysis of p-chlorophenyl-2-furohydroxamic acid | Health & Environmental Research Online (HERO)

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Citation
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HERO ID

6853653

Reference Type

Journal Article

Title

Kinetics and mechanistic study of acid-catalysed hydrolysis of p-chlorophenyl-2-furohydroxamic acid

Author(s)

Rajput, SK; Rajput, SK; Raghavan, V; Raghavan, V

Year

2007

Is Peer Reviewed?

Yes

Journal

Journal of the Indian Chemical Society
ISSN: 0019-4522

Volume

Issue

Page Numbers

588-592

Language

English

Web of Science Id

WOS:000248340600013

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-34648822724&partnerID=40&md5=e63bd5f9a03ea2d38514eef65b5fde1d
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Abstract

The rate of hydrolysis of p-chlorophenyl-2-furohydroxamic acid [4-Cl-C6H4N(OH)-C(O)-C4H3O] has been studied over a wide range of acidities in hydrochloric, sulphuric and perchloric acids in 20% (v/v) dioxane-water at 55 degrees C. The kinetics has been analysed by Bunnett, Bunnett-Olsen and Cox-Yates excess acidity treatments. Solvent, salt and temperature effects has also been probed. The mechanism of acid-catalysed hydrolysis is postulated as involving two steps : a rapid protonation and a rate-determining A-2 nucleophilic attack by water.<

Keywords

acid hydrolysis; heterocyclic acid; rate-acidity correlation