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6853755 
Journal Article 
SYNTHESIS OF NOVEL 3-(4-SUBSTITUTEDARYLOXYMETHYL) OXETAN-3-YLAMINES 
Reddy, TS; Reddy, TS; Vineel, BG; Vineel, BG; Naidu, A; Naidu, A; Dubey, PK; Dubey, PK 
2015 
Yes 
Indian Journal of Heterocyclic Chemistry
ISSN: 0971-1627 
24 
3 
345-348 
WOS:000354343300018 
2,2-Bis (bromomethyl) propane-1,3-diol (1) was cyclized in the presence of sodium ethoxide at room temp to obtain (3-(bromomethyl) oxetan-3-yl) methanol (2) which was treated with various phenols (3) to yield (3-(aryloxymethyl) oxetan-3-yl) methanol (4). The latter, on oxidation with KMnO4 in aq. NaOH containing dioxan gave the corresponding carboxylic acid derivatives 5.5 with benzyl alcohol containing Diphenyl Phosphoryl Azide (DPPA) gave 3-(4-substitutedaryloxymethyl) oxetan-3-ylamines (7) via N-CBz protected aminooxetanes (6).< 
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