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68543 
Journal Article 
Study of subacute toxicity of manganese dioxide in monkeys 
Suzuki, Y; Mouri, T; Suzuki, Y; Nishiyama, K; Fujii, N; Yano, H 
1975 
1 
Tokushima Journal of Experimental Medicine
ISSN: 0040-8875 
22 
5-10 
English 
821178 
BCI:BCI197662034806 
Monkeys [Macaca mulatta] developed extrapyramidal symptoms by s.c. administration of manganese dioxide. The degree of the symptoms was not dose-related but the higher the dosage level the faster was the onset of the symptoms. The animals receiving Mn showed hematologically anemic findings and a fall in the serum albumin-globulin ratio. Mn concentrations in various organs and tissues were closely related to the dose. The accumulation of the metal was prominent in the thyroids, parotids, gall bladder and in the nuclei of cerebral basal ganglia. Histopathological examination failed to reveal any adverse change in the lungs, liver, kidney, adrenals, lymph nodes and in the CNS including the nuclei of basal ganglia.