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6854966 
Journal Article 
Rapid quantitative determination of 1,4-dioxane in cosmetics by gas chromatography mass spectrometry 
Song, DM; Zhang, S; Zhang, WW; Kohlhof, K 
1996 
0 
Journal of the Society of Cosmetic Chemists
ISSN: 0037-9832 
SOC COSMETIC CHEMISTS 
NEW YORK 
47 
3 
177-184 
English 
WOS:A1996WD12500005 
Dioxane is a potential carcinogen. Determination of the level of dioxane present in cosmetics is of importance. A highly sensitive and accurate gas chromatography/mass spectrometry method for the rapid quantitative analysis of dioxane in cosmetics is described. Dioxane was extracted from a sample by hexane and methylene chloride (80:20, v/v) and then transferred to a C-8 solid-phase extraction (SPE) cartridge and eluted by acetonitrile. An aliquot of this solution was analyzed by gas chromatography/mass spectrometry with electron impact ionization (EI) and a selected ion monitoring (SIM) (dioxane m/z = 88) mode. The quantitative limit was set to be 0.1 ppm (0.1 mu g/g for cosmetics) with an injection volume of 2 mu l. The isotopically labeled dioxane-d(8) (m/z = 96) was used as an internal standard. 
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