Improved oxidation of active methyl group of N-heteroaromatic compounds by selenium dioxide in the presence of tert-butyl hydroperoxide | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

6855218

Reference Type

Journal Article

Title

Improved oxidation of active methyl group of N-heteroaromatic compounds by selenium dioxide in the presence of tert-butyl hydroperoxide

Author(s)

Tagawa, Y; Tagawa, Y; Yamashita, K; Yamashita, K; Higuchi, Y; Higuchi, Y; Goto, Y; Goto, Y

Year

2003

Is Peer Reviewed?

Yes

Journal

Heterocycles
ISSN: 0385-5414

Volume

Issue

Page Numbers

953-957

Web of Science Id

WOS:000182390300022

Abstract

The oxidation of active methyl group of N-heteroaromatic compounds including both of bicyclic and monocyclic compounds using SeO2 was considerably improved in the presence of tert-butyl hydroperoxde in dioxane to give the corresponding aldehyde or carboxylic acid in the moderate to good yields. The present oxidation proceeds more mildly and more selectively to form aldehyde rather than carboxylic acid, compared with conventional SeO2 oxidation without tert-butyl hydroperoxide.<