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6855616 
Journal Article 
A method for selective N-Boc deprotection on Wang resin 
Trivedi, HS; Trivedi, HS; Anson, M; Anson, M; Steel, PG; Steel, PG; Worley, J; Worley, J 
2001 
1 
Synlett
ISSN: 0936-5214
EISSN: 1437-2096 
2001 
12 
1932-1934 
WOS:000172596400031 
A simple, inexpensive and efficient method for the selective cleavage of N-Boc protecting group under acidic conditions on high load Wang resin is described. This method employs the use Of concd Sulfuric acid in 1.4-dioxan and provides an efficient process for the complete Boc deprotection with minimal loss of substrate through cleavage from resin.< 
solid phase synthesis; selective N-Boc cleavage; high load Wang resin