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6855874 
Meetings & Symposia 
Lactide polymerization faced with therapeutic application requirements 
Vert, M; Vert, M 
2000 
1 
Macromolecular Symposia
ISSN: 1022-1360
EISSN: 1521-3900 
153 
1 
333-342 
WOS:000087720400030 
The ring opening polymerization of cyclic dilactones of the 1,4-dioxane-2,5-dione-type derived from a-hydroxy acids such as lactic and glycolic acids leads to hydrolytically degradable and bioresorbable aliphatic polyesters of the poly(alpha-hydroxy acid)-type (PLAGA). Nowadays, taking advantage of the PLAGA family for therapeutic applications is one of the attractive area in polymer science. With such rationale, any advantages expected from advances from the Viewpoint of the science of polymeric materials have to be confronted to the chemical, physico-chemical, physical and biological phenomena imposed by living systems and media. The result is generally a compromise necessarily issued from a multidisciplinary approach. This contribution discusses the problem in general on the basis of the present understanding of the synthesis, the architecture and the hydrolytic degradation of PLAGA macromolecules confronted to biocompatibility and biofunctionality requirements.<