US EPA

6857440 

Journal Article 

Review 

Nucleoside 5′-triphosphates: self-association, acid–base, and metal ion-binding properties in solution 

Sigel, H; Griesser, R; , 

2005 

Yes 

Chemical Society Reviews
ISSN: 0306-0012
EISSN: 1460-4744 

34 

10 

875 

English 

16172677 

10.1039/b505986k 

WOS:000232003100006 

http://xlink.rsc.org/?DOI=b505986k
Exit
 

Adenosine 5'-triphosphate (ATP(4-)) and related nucleoside 5'-triphosphates (NTP(4-)) serve as substrates in the form of metal ion complexes in enzymic reactions taking part thus in central metabolic processes. With this in mind, the coordination chemistry of NTPs is critically reviewed and the conditions are defined for studies aiming to describe the properties of monomeric complexes because at higher concentrations (>1 mM) self-stacking may take place. The metal ion (M(2+)) complexes of purine-NTPs are more stable than those of pyrimidine-NTPs; this stability enhancement is attributed, in accord with NMR studies, to macrochelate formation of the phosphate-coordinated M(2+) with N7 of the purine residue and the formation degrees of the resulting isomeric complexes are listed. Furthermore, the formation of mixed-ligand complexes (including also those with buffer molecules), the effect of a reduced solvent polarity on complex stability and structure (giving rise to selectivity), the use of nucleotide analogues as antiviral agents, and the effect of metal ions on group transfer reactions are summarized.