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6858142 
Journal Article 
Comparative validation of quetiapine Determination in tablets by NP-HPTLC and RP-HPTLC with densitometric and videodensitometric detection 
Skibiński, R; Komsta, Ł; Kosztyła, I; , 
2008 
Yes 
Journal of Planar Chromatography - Modern TLC
ISSN: 0933-4173 
AKADEMIAI KIADO RT 
BUDAPEST 
21 
4 
289-294 
English 
WOS:000260364200013 
Two new simple and accurate methods for determination of quetiapine in tablets-normal phase (NP) and reversed-phase (RP) high performance thin layer chromatography (HPTLC), each with densitometric and videodensitometric detection, were developed and validated. NP-HPTLC was developed with HPTLC silica F254 plates and hexane-dioxane-propylamine 1:9:0.4 (v/v) as mobile phase. RPHPTLC was carried out using HPTLC RP8 F254 plates with tetrahydrofuran-phosphate buffer, pH 9.0, 5:5 (v/v) as mobile phase. The silica gel plates were developed to a distance of 9 cm and RP8 plates to a distance of 4.5 cm. Both analyses were performed in horizontal chambers and scanned with a densitometer at 243 nm and a video-densitometer at 254 nm. Calibration plots were linear in the range 0.2-1.2 μg quetiapine per spot for NP-HPTLC and in the range 0.1-1.1 μg for RP-HPTLC. The precision and accuracy of the four methods were fully compared and no significant differences were observed. The methods can be used in routine pharmaceutical analysis. © 2008 Akadémiai Kiadó. 
Quetiapine; Atypical antipsychotic drugs; HPTLC; Densitometry; Videodensitometry 
6h International Symposium on Chromatography of Natural Products 
Lublin, POLAND