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HERO ID
6859187
Reference Type
Journal Article
Title
Form Follows Function: Nanoparticle Shape and Its Implications for Nanomedicine
Author(s)
Kinnear, C; Moore, TL; Rodriguez-Lorenzo, L; Rothen-Rutishauser, B; Petri-Fink, A; ,
Year
2017
Is Peer Reviewed?
Yes
Journal
Chemical Reviews
ISSN:
0009-2665
EISSN:
1520-6890
Publisher
AMER CHEMICAL SOC
Location
WASHINGTON
Volume
117
Issue
17
Page Numbers
11476-11521
Language
English
PMID
28862437
DOI
10.1021/acs.chemrev.7b00194
Web of Science Id
WOS:000411044000008
URL
https://pubs.acs.org/doi/10.1021/acs.chemrev.7b00194
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Abstract
This review is a comprehensive description of the past decade of research into understanding how the geometry and size of nanoparticles affect their interaction with biological systems: from single cells to whole organisms. Recently, there has been a great deal of effort to use both the shape and the size of nanoparticles to target specific cellular uptake mechanisms, biodistribution patterns, and pharmacokinetics. While the successes of spherical lipid-based nanoparticles have heralded marked changes in chemotherapy worldwide, the history of asbestos-induced lung disease casts a long shadow over fibrous materials to date. The impact of particle morphology is known to be intertwined with many physicochemical parameters, namely, size, elasticity, surface chemistry, and biopersistence. In this review, we first highlight some of the morphologies observed in nature as well as shapes available to us through synthetic strategies. Following this we discuss attempts to understand the cellular uptake of nanoparticles through various theoretical models before comparing this with observations from in vitro and in vivo experiments. In addition, we consider the impact of nanoparticle shape at different size regimes on targeting, cytotoxicity, and cellular mechanics.
Keywords
article; cytotoxicity; drug therapy; in vivo studies; mechanics; nanomedicine; nanoparticles; pharmacokinetics; physicochemical properties; respiratory tract diseases; uptake mechanisms
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OPPT_Asbestos, Part I: Chrysotile_Supplemental Search
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