Wushan deposit is a large copper deposit located in the Jiu-Rui mineralization concentrated area in the Middle and Lower Yangtze Reaches, South China. [if this study, we report mineral chemistry, major, trace clervents, and Sr-Nd-Hf isotopic compositions of the ore-related granodiorite at Wushan. The biotites are Mg-riched and belong to phlogopile, which Fe3+/Fe2+ ratios indicating a high oxygen fugitive (f(02)) for the rnagnia. The aniphiboles show high Mg/Mg + Fe) and low Si, and belong, to actinolie and magnesiohornblende. The hornblende geobarometer indicates art ultra-shallow emplacement of the gianodiorite. The rocks show geochemical characteristics of adakitic affinity with high SiO2 (64.9% similar to 68.62%, average 66.52%) and Al2O3 (14.0% - 15.3% average 14.9%), and high Mg-# (0.53-0.71). The trace elernents are characterized by enrichment of K, Rh, Ba and Th, depletion of Nb, Ta, and Ti, high Sr, low Y, Sr/Y ratios of 35.0-68.2, and higher contents of V, Cr, Co and Ni. The REE characteristics are LREE enriched with (La/Yb), ratio of 27.8 -64.5, and lack any significant negative Eu anornaly. The initial Sr-17/(11)St. ratios are low from 0.7067 to 0.7075, and the epsilon(Nd)(t) values are high at -4.09 to -4.44. The zircon Hf isotope analysis shows epsilon(Hf) (t) values of -2.1 to -7.0. These data suggested that the Wilshan granodiorite was produced by strong crust-mantle interaction with very high proportion of mantle component, and was most likely derived from partial ruching of delaminated lower crust it around 145Ma. During its ascent, the magma may possibly have reacted with surrounding mantle peridotites.