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68637 
Journal Article 
Comparison of the neurotoxicity of several chemicals estimated by the peripheral nerve conduction velocity in rats 
Teramoto, K; Wakitani, F; Horiguchi, S; Jo, T; Yamamoto, T; Mitsutake, H; Nakaseko, H 
1993 
Yes 
Environmental Research
ISSN: 0013-9351
EISSN: 1096-0953 
ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS 
SAN DIEGO 
NIOSH/00215987 
62 
1 
148-154 
English 
8325260 
WOS:A1993LM61300017 
Estimates were made of peripheral nerve conduction velocity in rats in an effort to determine the comparative neurotoxicity of several chemicals. Forty male Wistar-rats were used in the study. Twelve were dosed with lead-acetate (301042) at dose levels to provide a 1% lead (7439921) concentration in their solid food. Others were fed a 5% lead concentration. They were fed on these diets from age 8 to 36 weeks and then given ordinary solid food to 56 weeks of age. Motor nerve conduction velocity and sensory nerve conduction velocity were measured when the rats were 8, 12, 20, 28, 36, 40, 44, 48, 52, and 56 weeks old. Other rats were exposed to manganese (7439965), 2-propanol (67630) or styrene (100425). All of the chemicals studied caused changes in the peripheral nerve conduction velocity. Their effects on sensory nerve conduction velocity were greater than their effects on motor nerve conduction velocity, and changes caused by the chemicals disappeared when administration or exposure ended. The effects on rat caudal nerve conduction velocity were greatest for lead, followed in decreasing order of severity by styrene, 2-propanol, and manganese. 
DCN-215732; Heavy metal poisoning; Lead poisoning; Laboratory animals; Nervous system disorders; Neurotoxicity; Central nervous system; Lead compounds; Manganese compounds; Comparative toxicology 
4TH INTERNATIONAL SYMP ON NEUROBEHAVIORAL METHODS AND EFFECTS IN OCCUPATIONAL AND ENVIRONMENTAL HEALTH 
TOKYO, JAPAN