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6864565 
Journal Article 
Malignant Pleural Mesothelioma: History, Controversy, and Future of a Man-Made Epidemic 
Roe, OD; Stella, GM; , 
2017 
SPRINGER INTERNATIONAL PUBLISHING AG 
CHAM 
ASBESTOS AND MESOTHELIOMA 
73-101 
WOS:000417711100004 
Asbestos (Greek, inextinguishable) is the term of a family of naturally occurring minerals that have been used in small scale since ancient times. Industrialization demanded increased mining and refining in the twentieth century, and in 1960, Wagner, Sleggs, and Marchand from South Africa linked asbestos to mesothelioma, paving the way to the current knowledge about the epidemiology, etiology, and biology of malignant pleural mesothelioma. Pleural mesothelioma is one of the most lethal cancers with increasing incidence worldwide. This review provides some snapshots of the history of mesothelioma discovery and the body of epidemiological and biological research including some of the controversies and unresolved questions. Molecular high-throughput profiling is currently unravelling novel biomarkers for earlier diagnosis and novel treatment targets. Current breakthrough discoveries of clinically promising non-invasive biomarkers such as mesothelin, the 13-protein signature in serum, fibulin-3, circulating microRNAs and the recently discovered BAP1 cancer syndrome are highlighted. The asbestos history is a lesson not be repeated, but here we also review recent in vivo and in vitro studies showing that man-made carbon nanofibers could pose a similar danger to human health. This should be taken seriously by regulatory bodies to ensure thorough testing of novel materials before release into society. 
Testa, JR; 
978-3-319-53558-6