US EPA

6865 

Book/Book Chapter 

Deposition and clearance of inhaled particles 

Schlesinger, RB 

1995 

Taylor & Francis 

Washington, DC 

Concepts in inhalation toxicology 

191-224 

English 

is related to other part(s) 004260 Species comparisons for pulmonary retention of inhaled particles
is related to other part(s) 072320 Deposition and clearance of inhaled particles

I. The biologic effects of inhaled particles are a function of their disposition. This, in turn, depends upon their patterns of deposition, i.e., the sites within which they initially come into contact with airway epithelial surfaces and the amounts removed from the inhaled air at these sites, and clearance, i.e., the rates and routes by which deposited particles are physically removed from the respiratory tract. For materials, such as irritants, which exert their action upon surface contact, the initial deposition is the predicator of toxic response. In many other cases, however, it is the net result of deposition and clearance--namely retention, i.e., the amount of particles remaining in the respiratory tract at specific times after exposure--which influences toxicity This chapter provides an overview of the processes by which airborne particles are deposited within and cleared from the respiratory tract. 

2 

McClellan, RO; Henderson, RF 

9781560323686