US EPA

6868382 

Journal Article 

Review 

Asbestos, Smoking and Lung Cancer: An Update 

Klebe, S; Leigh, J; Henderson, DW; Nurminen, M 

2019 

Yes 

International Journal of Environmental Research and Public Health
ISSN: 1661-7827
EISSN: 1660-4601 

17 

1 

258 

English 

31905913 

10.3390/ijerph17010258 

WOS:000509391500258 

https://www.mdpi.com/1660-4601/17/1/258
Exit
 

This review updates the scientific literature concerning asbestos and lung cancer, emphasizing cumulative exposure and synergism between asbestos exposure and tobacco smoke, and proposes an evidence-based and equitable approach to compensation for asbestos-related lung cancer cases. This update is based on several earlier reviews written by the second and third authors on asbestos and lung cancer since 1995. We reevaluated the peer-reviewed epidemiologic studies. In addition, selected in vivo and in vitro animal studies and molecular and cellular studies in humans were included. We conclude that the mechanism of lung cancer causation induced by the interdependent coaction of asbestos fibers and tobacco smoke at a biological level is a multistage stochastic process with both agents acting conjointly at all times. The new knowledge gained through this review provides the evidence for synergism between asbestos exposure and tobacco smoke in lung cancer causation at a biological level. The evaluated statistical data conform best to a multiplicative model for the interaction effects of asbestos and smoking on the lung cancer risk, with no requirement for asbestosis. Any asbestos exposure, even in a heavy smoker, contributes to causation. Based on this information, we propose criteria for the attribution of lung cancer to asbestos in smokers and non-smokers. 

Asbestosis; Carcinoma; Cumulative exposure; Mesothelioma; Multiplicative model; Pathogenesis; Smoking; Synergism