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6869528 
Journal Article 
Prostate Cancer and Asbestos: A Systematic Review and Meta-Analysis 
Dutheil, F; Zaragoza-Civale, L; Pereira, B; Mermillod, M; Baker, JS; Schmidt, J; Moustafa, F; Navel, V 
2020 
24 
2 
English 
32097115 
INTRODUCTION: Asbestos-related diseases and cancers represent a major public health concern.

OBJECTIVE: To conduct a systematic review and meta-analysis to demonstrate that asbestos exposure increases the risk of prostate cancer.

METHODS: The PubMed, Cochrane Library, Embase, and ScienceDirect databases were searched using the keywords (prostate cancer OR prostatic neoplasm) AND (asbestos* OR crocidolite* OR chrysotile* OR amphibole* OR amosite*). To be included, articles needed to describe our primary outcome: Risk of prostate cancer after any asbestos exposure.

RESULTS: We included 33 studies with 15,687 cases of prostate cancer among 723,566 individuals. Asbestos exposure increased the risk of prostate cancer (effect size = 1.10, 95% confidence interval [CI] = 1.05-1.15). When we considered mode of absorption, respiratory inhalation increased the risk of prostate cancer (1.10, 95% CI = 1.05-1.14). Both environmental and occupational exposure increased the risk of prostate cancer (1.25, 95% CI = 1.01-1.48; and 1.07, 1.04-1.10, respectively). For type of fibers, the amosite group had an increased risk of prostate cancer (1.12, 95% CI = 1.05-1.19), and there were no significant results for the chrysotile/crocidolite group. The risk was higher in Europe (1.12, 95% CI = 1.05-1.19), without significant results in other continents.

DISCUSSION: Asbestos exposure seems to increase prostate cancer risk. The main mechanism of absorption was respiratory. Both environmental and occupational asbestos exposure were linked to increased risk of prostate cancer.

CONCLUSION: Patients who were exposed to asbestos should possibly be encouraged to complete more frequent prostate cancer screening. 
OPPT REs
• OPPT_Asbestos, Part I: Chrysotile_Supplemental Search
     LitSearch: Sept 2020 (Undated)
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