Synthesis of 2 '-(substituted)benzylidene hydrazino-5-arylamino-1,3,4-thiadiazoles and their antimicrobial activity | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

6918960

Reference Type

Journal Article

Title

Synthesis of 2 '-(substituted)benzylidene hydrazino-5-arylamino-1,3,4-thiadiazoles and their antimicrobial activity

Author(s)

Burghate, MK; Gandhe, SV; Ajmire, MG; Berad, BN; ,

Year

2007

Is Peer Reviewed?

Yes

Journal

Journal of the Indian Chemical Society
ISSN: 0019-4522

Publisher

INDIAN CHEMICAL SOC

Location

CALCUTTA

Volume

Issue

Page Numbers

103-108

Language

English

Web of Science Id

WOS:000244282700018

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-34648813135&partnerID=40&md5=a9cc4179feac4b2be65daa16ea91a1cb
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Abstract

Several 2'-(substituted)benzylidene hydrazino-5-arylamino-1,3,4-thiadiazoles (5a-m) have been synthesized by the condensation of 1-(N-aryl thioamido)thiocarbohydrazides (3a-f) and different aromatic aldehydes in benzene medium, followed by intramolecular cyclization of compounds (4a-m) in refluxing ethanol medium. The former in turn have been prepared by the reaction of aryl isothiocynates (2a-f) and thiocarbohydrazide (1). Compounds (5a-m) on bromination with bromine in glacial acetic acid afforded dibromo The synthesized compounds were assayed for their antimicrobial activity against gram positive as well as gram negative micro-organisms.