Activated alumina ball catalyzed expeditious synthesis of 2-alkylbenzimidazoles with special emphasis on susceptible side chains possessing amide functionality | Health & Environmental Research Online (HERO)

Health & Environmental Research Online (HERO)

Print Feedback Export to File

This record has one attached file:

Citation
Tags

HERO ID

6919049

Reference Type

Journal Article

Title

Activated alumina ball catalyzed expeditious synthesis of 2-alkylbenzimidazoles with special emphasis on susceptible side chains possessing amide functionality

Author(s)

Ghosh, S; Hudrlik, A; Mukhopadhyay, C; ,

Year

2013

Is Peer Reviewed?

Yes

Journal

Journal of the Indian Chemical Society
ISSN: 0019-4522

Publisher

SCIENTIFIC PUBL-INDIA

Location

JODHPUR

Volume

Issue

Page Numbers

1737-1748

Language

English

Web of Science Id

WOS:000209279700022

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84891301158&partnerID=40&md5=3f17d781e775bde96e08bf96eb7b5614
Exit

Abstract

A solvent- and chromatography-free, non-hazardou green protocol for the synthesis of 2-alkylbenzimidazoles has been.developed under neutral conditions with water as the only by-product. Activated alumina balls, which have been shown previously to assist in amidation reaction, also catalyze very successfully the condensation of benzene-1,2-diamines with carboxylic acids to produce the corresponding benkimidazoles. This methodology is also applicable to susceptible side chains possessing an amide functionality.