Synthesis and biological activity of 7H-benzo[4,5]indolo[2,3-b]-quinoxaline derivatives | Health & Environmental Research Online (HERO)

Health & Environmental Research Online (HERO)

Print Feedback Export to File

This record has one attached file:

Citation
Tags

HERO ID

6927744

Reference Type

Journal Article

Title

Synthesis and biological activity of 7H-benzo[4,5]indolo[2,3-b]-quinoxaline derivatives

Author(s)

Shibinskaya, MO; Karpenko, AS; Lyakhov, SA; Andronati, SA; Zholobak, NM; Spivak, NY; Samochina, NA; Shafran, LM; Zubritsky, MJ; Galat, VF; ,

Year

2011

Is Peer Reviewed?

Yes

Journal

European Journal of Medicinal Chemistry
ISSN: 0223-5234
EISSN: 1768-3254

Publisher

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER

Location

ISSY-LES-MOULINEAUX

Volume

Issue

Page Numbers

794-798

Language

English

PMID

21172726

DOI

10.1016/j.ejmech.2010.11.040

Web of Science Id

WOS:000287617500035

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-79151476740&doi=10.1016%2fj.ejmech.2010.11.040&partnerID=40&md5=8101b56281f49a9a8e3e4cc4355e9b50
Exit

Abstract

New 7-(2-aminoethyl)-7H-benzo[4,5]indolo[2,3-b]quinoxalines (13-20) were synthesized with high yields starting from 3H-benzo[e]indole-1,2-dione. These compounds were screened for the cytotoxicity, anti-viral activity, interferon inducing ability and DNA affinity compared with the corresponding 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxaline derivatives (1-12). It was shown, that compounds 13-20 bind to DNA stronger (lg Кa=6.23-6.87) than compounds 1-12 (lg Кa=5.57-5.89). Anti-viral activity is significantly reduced with annulations of benzene ring in Indoloquinoxaline moiety 13-20.