Synthesis of Some Novel 5-(Arylidene)-2-imino-3(pyridin-2-yl)thiazolidin-4-one Derivatives | Health & Environmental Research Online (HERO)

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HERO ID

6928110

Reference Type

Journal Article

Title

Synthesis of Some Novel 5-(Arylidene)-2-imino-3(pyridin-2-yl)thiazolidin-4-one Derivatives

Author(s)

Mobinikhaledi, A; Foroughifar, N; Faghihi, S; ,

Year

2009

Is Peer Reviewed?

Journal

Phosphorus, Sulfur, and Silicon and the Related Elements
ISSN: 1042-6507
EISSN: 1563-5325

Publisher

TAYLOR & FRANCIS LTD

Location

ABINGDON

Volume

184

Issue

Page Numbers

1837-1842

Language

English

DOI

10.1080/10426500802387401

Web of Science Id

WOS:000277672400019

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-70449635543&doi=10.1080%2f10426500802387401&partnerID=40&md5=aeb6aa4f672fd3e07b5ac553bd1fd379
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Abstract

Treatment of 2-aminopyridine (1) with chloroacetyl chloride in dry benzene gave 2-chloro-N-(pyridin-2-yl)acetamide (3), which on further reaction with potassium thiocyanate gave 2-imino-3-(pyridin-2-yl)thiazolidin-4-one (4) as an intermediate compound for the synthesis of pyridin-2-yl substituted 2-imino-thiazolidine-4-one derivatives. Cyclocondensation reaction of (4) with a series of aromatic aldehydes gave 5-arylidene derivatives of pyridin-2-yl substituted 2-imino-thiazolidine-4-ones 5a-j. (1)H and (13)C NMR spectroscopy, as well as elemental analyses, were used for the identification of these new compounds.