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HERO ID
6928760
Reference Type
Journal Article
Title
Novel 3-sulphonamido-quinazolin-4(3H)-one derivatives: microwave-assisted synthesis and evaluation of antiviral activities against respiratory and biodefense viruses
Author(s)
Selvam, P; Vijayalakshimi, P; Smee, DF; Gowen, BB; Julander, JG; Day, CW; Barnard, DL; ,
Year
2007
Is Peer Reviewed?
Yes
Journal
Antiviral Chemistry and Chemotherapy
ISSN:
0956-3202
EISSN:
2040-2066
Volume
18
Issue
5
Page Numbers
301-305
Language
English
PMID
18046963
DOI
10.1177/095632020701800506
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-36849018430&doi=10.1177%2f095632020701800506&partnerID=40&md5=45b6c7ca1e2cdd840003f7ea35fa2de3
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Abstract
We designed and synthesized novel 2,3-disubstituted quinazolin-4(3H)-ones by microwave technique and characterized them by spectral analysis. Synthesized compounds were screened for cytotoxicity and for antiviral activity against influenza A (H1N1, H3N2 and H5N1), severe acute respiratory syndrome corona, dengue, yellow fever, Venezuelan equine encephalitis (VEE), Rift Valley fever, and Tacaribe viruses in cell culture. A neutral red uptake assay was used to determine 50% virus-inhibitory concentrations (EC50) of test compounds and their 50% cytotoxicity concentration (CC50) in uninfected Madin-Darby canine kidney, Vero, and Vero 76 cells; selectivity indices (ratio of CC50 to EC50) were derived from the data. The compound 4-(6,8-dibromo-4-oxo-2-phenyl quinazolin-3(4H)-yl)-N-(4,5-dimethyloxazol-2yl) benzenesulphonamide 15 inhibited the replication of avian influenza (H5N1) virus (EC50 = 8.4 microg/ml, CC50 > 100 microg/ml, SI > 11.9) as did 4-(6-bromo-4oxo-2phenylquinazolin-3(4H)-yl) benzene]sulphonamide 5 (EC50 = 3 microg/ml, CC50 = 32 microg/ml, SI = 11). Compound 5 was also moderately active against VEE and Tacaribe viruses. The methodology described in this report is applicable for rapid synthesis of many compounds with potential antiviral properties.
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