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6933629 
Journal Article 
Development of a benzene-induced AML model in CBA/Ca mice with bone marrow immunophenotypic features 
He, J; Zang, S; Ji, M; Ma, D; Ji, C 
2018 
Yes 
International Journal of Clinical and Experimental Medicine
ISSN: 1940-5901 
11 
8 
7710-7718 
English 
WOS:000443533700020 
Objective: Acute myeloid leukemia (AML) is a hematological disease which has been associated with long-term exposure to benzene (BZ) vapors. To develop an animal model of secondary leukemia, BZ can be used as leukemogenic agent. Despite the high frequency of AML is observed in human cases of occupational exposure to BZ, but not commonly observed in mice. Moreover, the association between the BZ exposure and the cause of AML remained incomplete. Methods: We used the CBA/Ca mouse as a model, exhibited a susceptible to AML, allowing investigation into the immunotoxicity effects associated with benzene-induced acute leukemia. Results: Body weight was decreased significantly after 8 weeks BZ exposure in the BZ-acute myeloid leukemia (BZ-AML) group compared with the control group. After 8 weeks of BZ exposure, the BZ-AML model group was associated with an enlarged liver and spleen. Furthermore, molecular studies demonstrated that BZ-induced acute leukemia was closely linked to NLRP3 overexpression, which was in response to impaired immune function. Thus, the CBA/Ca mouse can provide an excellent model for the development of therapeutic strategies against BZ-induced leukemia and allow for study of the molecular etiology in more depth. Conclusions: We developed a BZ-induced AML model in CBA/Ca mice with bone marrow immunophenotypic features.