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6934226 
Journal Article 
Three new C23 steroids from the leaves and stems of Nicandra physaloides 
Zhang, L; Peng, X; Zhao, G; Xia, J; Lu, J; Zhou, Lin; Wang, K; Li, Z; Qiu, M; , 
2019 
1 
Steroids
ISSN: 0039-128X
EISSN: 1878-5867 
ELSEVIER SCIENCE INC 
NEW YORK 
150 
English 
31201842 
WOS:000486110300002 
Nicandra physaloides is a medicinal and edible plant and has been used as traditionally herbal medicine to treat various diseases in folk. Its characteristic withanolides, a kind of ergostane-type steroids, are reported to display plentiful biological activities that many explain the effect of N. physaloides to some extent. Thus, to further find bioactive steroids, the stems and leaves of N. physaloides were investigated and three new C23 steroids, nic-physatones I-J (1-2), and nic-physatone S (3), together with a known C25 steroid, nic 17 (4), were isolated. Their structures were elucidated by extensive 1D NMR and 2D NMR (HSQC, HMBC, H-1-(1) H COSY, and ROESY), UV and MS analyses. Compounds 1-3 possess a rare C23 steroid skeleton. Among them, compound 3 represented the first example of a C23 steroid featuring a benzene ring (D ring). The isolated compounds showed no cytotoxic activity.