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6934673 
Journal Article 
Maternal exposure to benzene and toluene and preterm birth. A longitudinal study 
Almeida dos Santos, DA; Costa Nascimento, LF; , 
2019 
1 
Sao Paulo Medical Journal
ISSN: 1516-3180 
ASSOCIACAO PAULISTA MEDICINA 
SAO PAULO 
137 
6 
486-490 
English 
32159633 
WOS:000528273300003 
BACKGROUND: Exposure to air pollutants has several effects on human health, including during pregnancy.OBJECTIVE: To identify whether exposure to benzene and toluene among pregnant women contributes to preterm delivery.DESIGN AND SETTING: Longitudinal study using data on newborns from mothers living in Sao Jose dos Campos (SP) in 2016, who had been exposed to benzene and toluene.METHODS: A logistic regression model with three hierarchical levels was constructed using maternal variables relating to newborns, and using benzene and toluene concentrations in quartiles. Occurrences of cesarean births, twins or malformations were excluded. Maternal exposure windows of 5, 10, 15, 30, 60 and 90 days prior to delivery were considered.RESULTS: Out of the 9,562 live births, 3,671 newborns were included and 343 newborns were born at less than 37 weeks of gestation (9.3%). The average birth weight was 3,167.2 g. Exposure to benzene and toluene was significantly associated (P = 0.04) with preterm delivery in the five-day window. There was no association in any of the other exposure windows.CONCLUSIONS: It was possible to identify that maternal exposure to benzene and toluene has an acute effect on preterm delivery. 
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