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6934888 
Journal Article 
Comparison of platelet rich fibrin and collagen as osteoblast-seeded scaffolds for bone tissue engineering applications 
Gassling, V; Hedderich, J; Açil, Y; Purcz, N; Wiltfang, J; Douglas, T; , 
2013 
Yes 
Clinical Oral Implants Research
ISSN: 0905-7161
EISSN: 1600-0501 
WILEY 
HOBOKEN 
24 
3 
320-328 
English 
22092514 
WOS:000314656500012 
The loss of jaw bone caused by different kinds of pathologies leads to dysfunction and reduced quality of life in affected patients. Thus, the pivotal goal in bone tissue engineering is to reconstruct these defects. The essential precondition for new tissue generation is an extracellular matrix which acts as a scaffold so that cells can migrate, differentiate, and proliferate. Fibrin, a biopolymer responsible for blood clot formation, has been shown to be suitable for tissue engineering applications. The aim of the present study is a comparison of platelet rich fibrin (PRF) with the commonly used collagen membrane BioGide(®) as a scaffold for human osteoblast cell seeding for bone tissue engineering.