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6935487 
Journal Article 
Chemical Constituents from Chloranthus anhuiensis and Their Cytotoxic Activities 
Zhu, HL; Qu, W; Zhang, J; Guo, EY; Du, T; Liu, WY; Cao, WY; Feng, F; Xu, J; , 
2018 
Yes 
Chemistry & Biodiversity
ISSN: 1612-1872
EISSN: 1612-1880 
WILEY-V C H VERLAG GMBH 
WEINHEIM 
15 
10 
English 
30019425 
WOS:000447546100008 
Three hiherto unknown phenylpropanoid compounds, namely (7S,8R)-1-(1-ethoxy-2-hydroxypropyl)-2-methoxy-3,4-(methylenedioxy)benzene (1), (7S,8S)-1-(1-ethoxy-2-hydroxypropyl)-2-methoxy-3,4-(methylenedioxy)benzene (2), and (7S,8R)-1-(1-methoxy-2-hydroxypropyl)-2-methoxy-3,4-(methylenedioxy)benzene (3), along with 12 known compounds (4 - 15) were obtained from the extract of whole plant of Chloranthus anhuiensis. Among them, 7 and 13 were obtained from nature for the first time. The structures of these natural compounds were characterized by extensive spectroscopic analysis and calculated electronic circular dichroism (ECD) data. Furthermore, their cytotoxic and neuroprotective activities were evaluated using MDA-MB-231, 4T1, HepG2, and PC12 cell lines. Compounds 8 and 13 exhibited moderate cytotoxic activities against MDA-MB-231 cell line with the IC50 values of 39.7 and 25.8 μm, respectively. And all the isolated compounds have no neuroprotective activities.