Quantitative Nuclear Magnetic Resonance Spectroscopic Analysis of Valsartan in Bulk and Solid Oral Dosage Form | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

6936551

Reference Type

Journal Article

Title

Quantitative Nuclear Magnetic Resonance Spectroscopic Analysis of Valsartan in Bulk and Solid Oral Dosage Form

Author(s)

Kalaimagal, A; Hemalatha, PV; Suresh, AJ; Kumar, GSU; Niraimathi, V; ,

Year

2013

Is Peer Reviewed?

Yes

Journal

Asian Journal of Chemistry
ISSN: 0970-7077
EISSN: 0975-427X

Publisher

ASIAN JOURNAL OF CHEMISTRY

Location

SAHIBABAD

Volume

Issue

Page Numbers

4267-4270

Language

English

DOI

10.14233/ajchem.2013.13929

Web of Science Id

WOS:000317246400031

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84877273477&doi=10.14233%2fajchem.2013.13929&partnerID=40&md5=f829eca6e013454f7e17d448328b3988
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Abstract

NMR spectroscopy has been applied to the quantification of valsartan in bulk and pharmaceutical dosage form. The estimation was carried out by proton nuclear magnetic resonance spectroscopy using tetra chloro nitro benzene as an internal standard and deuterated chloroform as the NMR solvent. NMR patterns were recorded for both valsartan and tetra chloro nitro benzene in deuterated chloroform. The signals corresponding to the chemical shifts of 1.73 and 4.95 ppm for valsartan and 7.75 ppm for tetra chloro nitro benzene were considered for quantification process.