Health & Environmental Research Online (HERO)


Print Feedback Export to File
6945755 
Journal Article 
Synthesis & Anticancer Evaluation of New Substituted 2-(3,4- Dimethoxyphenyl)benzazoles 
Karaaslan, C; Duydu, Y; Ustundag, A; Yalcin, CO; Kaskatepe, B; Goker, H; , 
2019 
1 
Medicinal Chemistry
ISSN: 1573-4064
EISSN: 1875-6638 
15 
3 
287-297 
English 
29992893 
WOS:000464317300007 
The benzazole nucleus is found in many promising small molecules such as anticancer and antibacterial agents. Bendamustine (Alkylating agent), Nocodazole (Mitotic inhibitor), Veliparib (PARP inhibitor), and Glasdegib (SMO inhibitor) are being clinically used as anticancer therapeutic which bear benzimidazole moiety. Based on the principle of bioisosterism, in the present work, 23 compounds belonging to 2-(3,4-dimethoxyphenyl)benzazoles and imidazopyridine series were synthesized and evaluated for their anticancer and antimicrobial activities. 
3,4-Dimethoxyphenyl; NOESY; 1H-benzimidazole; imidazopyridine; benzoxazole; benzothiazole